The Link Between TMAO, ASF, and the Risks of Cardiovascular Disease

In recent years, criticism has grown of the health effects of consuming red and processed meat.

In particular, studies have suggested that there may be a link between consuming these foods and an increased risk of developing cardiovascular disease (CVD). One potential mechanism for this association is the production of trimethylamine-N-oxide (TMAO) in the gut after eating these foods.

A recent study published in Arteriosclerosis, Thrombosis, and Vascular Biology found an association between animal-source foods (ASF) and cardiovascular disease risk among older adults. This study showed that there might be more connections between ASF and the gut microbiome pathway than previously thought - and a greater risk of developing atherosclerotic cardiovascular disease (ASCVD).

During a median follow-up of 12 years, the risk of ASCVD was greater with each quintile of consumption of unprocessed red meat, total meat, and total ASF. Trimethylamine N-Oxide (TMAO) is a gut microbial metabolite linked with ASCVD.

In this study, researchers looked at the role of TMAO in mediating the relationship between ASF intake and incident ASCVD. They found that TMAO was associated with a greater risk of ASCVD and that this risk was partially mediated by TMAO - showing that TMAO may be one mechanism through which ASF consumption contributes to ASCVD risk.

While this study does not prove that ASF causes ASCVD, it adds to the growing body of evidence suggesting that there is a link between the two.

The Risks of TMAO

Trimethylamine N-oxide (TMAO) is a gut microbial metabolite that has been linked with atherosclerotic cardiovascular disease (ASCVD), and previous studies have shown that the production of TMAO increases after consuming animal-source foods (ASF). In this study, researchers looked at the role of TMAO in mediating the relationship between ASF intake and incident ASCVD.

They found that TMAO was associated with a greater risk of ASCVD and that this risk was partially mediated by TMAO - showing that TMAO may be one mechanism through which ASF consumption contributes to ASCVD risk. While this study does not prove that ASF causes ASCVD, it adds to the growing body of evidence suggesting that there is a link between the two.

So what exactly is TMAO, and why is it thought to be harmful?

TMAO is a by-product of choline and lecithin metabolism and is produced by gut bacteria. Choline is found in many foods, including ASF, and when it is metabolized by gut bacteria, TMAO is produced.

TMAO has been linked with ASCVD in several studies. It is thought to promote atherosclerosis (the buildup of plaque in the arteries) by promoting the accumulation of cholesterol in the arteries.

How to Reduce Your Risks

If you're concerned about the potential risks of TMAO, there are some steps you can take to reduce your exposure:

-Limit your consumption of ASF: This is the best way to reduce your exposure to TMAO and other potential risks associated with these foods.

-Choose leaner cuts of meat: This will help to reduce your exposure to fat and cholesterol, which can also contribute to ASCVD risk.

-Make sure you're getting enough fiber in your diet, as this can help promote a healthy gut microbiome.

-Consider taking a probiotic supplement, as this can help promote a healthy gut microbiome.

While more research is needed to fully understand the link between ASF, TMAO, and ASCVD, these steps can help reduce your risks. Another key is to work with a functional medicine practitioner to optimize your gut health, as a healthy gut microbiome is essential for overall health.

Learn More with Dr. Khan - The Woodland's Functional Medicine Leader

If you're interested in learning more about ASF, TMAO, and ASCVD, or looking for help optimizing your gut health, schedule a consultation with Dr. Khan at Internal Healing and Wellness today. As the leading functional medicine practitioner in The Woodlands, TX, Dr. Khan has extensive experience helping patients improve their gut health and achieve their overall health goals.

Dr. Khan will work with you to develop a personalized treatment plan that addresses your unique needs and helps you achieve your health goals. He may recommend dietary changes, supplements, lifestyle modifications, and other evidence-based therapies.

Setup a meeting with Dr. Khan today and start on the path to improved gut health and overall wellness.